In September 2019, the US Food and Drug Administration (FDA) approved Stendra, a drug commonly known as “the blue pill” that helps women with low sexual desire (LSD) achieve an erection. Although Stendra is similar to Viagra, it functions in a different way, and as a result, has different side effects. The drug is manufactured by Impax Laboratories and marketed by CVS Health in partnership with Stroma.[1] This article will explain what you need to know about Stendra.
Key Facts About Stendra
This drug is classified as a phosphodiesterase type 5 (PDE5) inhibitor. PDE5 inhibitors block the enzyme isoform 5, which is present in high levels in the corpus cavernosum. This is an area of the penis that fills with blood during an erection. The drug has been shown in clinical trials to increase the size of the penis by up to 4.6 inches (11.8 cm) and improve sexual function in women with mild to moderate LSD.[2] Stendra is also associated with an increased rate of spontaneous abortions, but the risk of this is considered to be low. It is not known whether the drug is safe during pregnancy. Men with liver problems should not take PDE5 inhibitors, as they may interfere with the function of the liver enzyme cytochrome P450.
How Does Stendra Work?
Steroids like testosterone and dihydrotestosterone (DHT) are “androgen” hormones. They act as “natural Viagra’s,” increasing the bloodflow to the genitals and encouraging the development of male sexual characteristics. However, during the last 10 years, scientists have been developing PDE5 inhibitors that can block the actions of these hormones and prevent erections from occurring. In the case of Stendra, the manufacturer claims that it produces “a powerful and reliable erection,” even in women. This has been seen as a significant advancement in the treatment of female erectile dysfunction (ED), and a step toward better healthcare for women in the future.
What Is the Difference Between Stendra and Viagra?
Stendra is a PDE5 inhibitor, and as a result, acts as a “vasopressin” (AVP) agonist. AVP is a hormone that causes the constriction of blood vessels. It is released during sexual arousal, and may play a role in producing and maintaining an erection. AVP is similar to a neurotransmitter called “nitric oxide,” which is responsible for the relaxation of blood vessels.[3]
Viagra is a popular drug that is often prescribed to men to treat ED. It works by inhibiting the enzyme called PDE5, which breaks down the “neurotransmitter” called “cyclic guanosine monophosphate,” or cGMP. As a result of this inhibition, men are claimed to achieve an erection that is harder and lasts longer. It is thought that Viagra may improve sexual function, increase the size of the penis, and even help men with infertility issues.[4]
What Are the Differences Between the Various Sides of Stendra?
The different sides of Stendra are as follows:
- Stendra (Sustained-release tablet): This is the form of the drug that is taken orally, and it provides a sustained release of the active ingredient. The manufacturer recommends this form for once-daily dosing. The tablet should be taken with water, and it can be used independently of food or any other medication. As with all oral medications, there may be an issue with swallowing the tablet, as it is larger than usual. Patients with liver problems should consult their doctors before taking this medication.
- Stendra (Sustained-release injection): This is the form of the drug that is injected directly into the vagina or the urethra, and it provides a sustained release of the active ingredient. The manufacturer recommends this form for patients who need highly effective blood-flow stimulation and who have difficulty swallowing the tablet. As with all vaginal medications, there is the potential for irritation and damage in the case of an overdose. Women who are breastfeeding or who are pregnant should not take this medication.
- Stendra (Elixir): This is the form of the drug that is used to treat vaginal infections, and it provides a sustained release of the active ingredient. The elixir should be applied directly to the vagina, avoiding contact with the vulva or the urethra. After applying the elixir, the patient should wash their hands before having sex. Like all vaginal medications, this one should not be taken by women who are breastfeeding or who are pregnant.
- Stendra (Gel): This is the form of the drug that is used to treat vaginal infections, and it provides a sustained release of the active ingredient. The gel should be applied directly to the vulva, avoiding contact with the vagina or the urethra. After applying the gel, there should be a 10-minute wait before having sex or masturbation. This allows the medicine to permeate the vaginal walls and the surrounding tissues. Like all vaginal medications, this one should not be taken in the morning, as it may interfere with the body’s ability to produce “natural” or “spontaneous” erections.
- Stendra (Injection, Pre-filled Syringe): This is the form of the drug that is injected directly into the urethra, producing a sustained release of the active ingredient. The injection should be injected directly into the meatus, which is the opening at the tip of the urethra. Like all urethral medications, this one should not be taken in the morning, as it may interfere with the body’s ability to produce “spontaneous” erections.
Benefits Of Taking Stendra
The benefits of Stendra are as follows: