The erectile dysfunction (ED) drug market was valued at US$16.9 billion in 2018 and is predicted to hit $26.9billion by 2023.

The global ED market was valued at US$16.9billion in 2018 and is predicted to hit $26.9billion by 2023.

How Do They Work?

Viagra and Cialis are both phosphodiesterase (PDE) inhibitors that enhance the effects of nitric oxide (NO) in the body by increasing the availability of nitric oxide in the blood vessels. When blood flows through the vessels, it encourages the relaxation of the muscles in the penile tissue, resulting in an erection.

Phosphodiesterase is an enzyme that breaks down cyclic adenosine monophosphate (cAMP), which is important for the functioning of all the body’s organs. There are four types of phosphodiesterase in the body:

  • PDE 5
  • PDE 6
  • PDE 9
  • PDE 10

However, not all phosphodiesterase inhibitors are the same. Viagra works by inhibiting PDE 5, which is present in large amounts in the human penis. This enzyme breaks down cAMP, leading to increased amounts of NO in the blood and tissues. In turn, the increased amount of NO encourages vasodilation and penile erection, as well as helps prevent cardiovascular disease.

On the other hand, Cialis is a more recent addition to the ED market and works by inhibiting PDE 6 and PDE 9. PDE 6 breaks down cAMP in the small neurons that communicate between the brain and the genitals, while PDE 9 breaks it down in the corpus cavernosum (the tissue in the penis that gets filled with blood during an erection). By inhibiting these enzymes, Cialis increases the effect of NO in the penis, resulting in improved erectile function and greater therapeutic efficacy.

Which One Is Better for You?

If you’re looking for a treatment for ED that has a history of clinical success, then you should probably go for Viagra. But, if you’re looking for a treatment that has a lesser known history of success and is more effective than the standard ED treatment, then you should probably go for Cialis. Let’s take a look at the pros and cons of each drug.

Viagra

Viagra is probably the most well-known and most popular of the ED drugs currently on the market. The active compound in Viagra is Sildenafil, which was approved for medical use in 1998. Sildenafil is a potent inhibitor of PDE 5, which is the enzyme that breaks down cAMP in the phosphodiesterase family. Sildenafil is also a competitive inhibitor of adenosine diphosphate (ADP) and inhibits platelet aggregation caused by ADP. This is important because a normal side effect of taking Viagra is that it can cause blood clots in some people, which may lead to strokes or heart attacks. In addition, taking Viagra can cause low blood pressure and facial flushing. These events are more common in people with heart problems.

However, Viagra is not always effective for people with heart problems, especially severe ones. A 2017 study published in the Journal of the American College of Cardiology found that only 46% of Viagra-initiated sex encounters in patients with unstable angina pectoris resulted in an erection durable enough for vaginal penetration. The study also noted that only 35% of the patients were able to complete vaginal penetration with their partner during the first sex encounter after taking Viagra, compared to 62% of the patients before they took the drug. In addition, 24% of the patients had to discontinue taking Viagra after experiencing a severe adverse effect. This includes 6% who had to drop the drug due to a significant drop in blood pressure and 8% who had to discontinue the treatment due to a facial flushing event.

Cialis

Cialis is a relatively new treatment for ED, having first been approved for medical use in 2012. The active chemical compound in Cialis is Tadalafil, which is a more selective inhibitor of PDE 6 and PDE 9 than Sildenafil. This means that it has a better side effect profile than Viagra and is more effective at treating ED in people with heart problems. In addition, Cialis can inhibit the enzyme that breaks down cAMP, which is important for people whose bodies cannot produce it endogenously, like those who have been on surgical diets for a long time or suffered from diabetes mellitus. Finally, the active compound in Cialis also acts as a weak antioxidant and free radical scavenger, protecting the body from damage by these unstable molecules.

Cialis has a more comprehensive list of side effects than Viagra, including headache, facial flushing, shortness of breath, dizziness, and hypotension (low blood pressure). However, these effects seem to be less common than with Viagra. A study published in 2018 in the Journal of Sexual Medicine examined the side effects of Cialis in men with ED and found that 17% had headaches, 11% had dizziness, and 7% had shortness of breath. But, none of the patients in the study had to discontinue treatment due to these side effects.

Which One Is Better for You?

Based on the information we have available, it would seem that Cialis is a better option for people whose ED is caused by a medical condition or who have recently undergone surgery. It also appears that Cialis is safer than Viagra in terms of its side effect profile. For those who have had a history of cardiovascular disease or are at risk of heart problems, Viagra would seem to be the safer option. But, if you’re looking for an ED treatment with a more established track record as well as one that is relatively safer and more effective than the standard treatment, then you should probably go with Cialis.

Which one is better for you depends on your personal preferences. But, if you’re looking for a drug to treat ED, then you should probably go with Cialis, especially since it appears to be safer and more effective than Viagra.

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