When the FDA approved Sildenafil (also known as Viagra) for sale, it was a breath of fresh air for men worldwide who were experiencing erectile dysfunction. The only problem was that, as with any drug or supplement, there was a dark side to this innovation. While most men report fantastic results from taking Sildenafil, there are others who report serious side effects such as heart attacks and strokes. Unfortunately, these cases are on the rise. Does this mean that all men who take Sildenafil should avoid heart disease and strokes? Definitely not! We’re just saying that you need to do some research before you start popping pills to increase your confidence level or lower your cholesterol.

The History Of Sildenafil

As previously mentioned, Sildenafil is a prescription drug used to treat erectile dysfunction. It was originally developed as a treatment for another condition called pulmonary arterial hypertension. This is a dangerous condition where the walls of the pulmonary arteries become thick and inflamed, causing the blood pressure in the arteries to rise. In patients with pulmonary arterial hypertension, Sildenafil helped relax the arteries and reduced the blood pressure.

Since then, it has become a popular treatment for ED. It’s available as both a generic and trademarked drug. The former is produced by several manufacturers, while the latter is produced by Pfizer. Sildenafil is also available in various dosages, including 100mg, 50mg, and 25mg. However, you should not use any less than 100mg. Taking less than this may cause serious problems.

Sildenafil In Clinical Trials

A total of 23 clinical trials were conducted in order to test the efficacy and safety of Sildenafil for the treatment of erectile dysfunction. Thirteen of these trials examined the efficacy and safety of Sildenafil in comparison to placebo. The others examined the effects of different doses of Sildenafil. One trial, specifically, compared Sildenafil 50mg to 100mg and found that the higher dose was superior, producing significantly better erections and fewer side effects. This was a randomized, double-blind study that was conducted at 41 centers across the world.

Another trial examined the efficacy and safety of Sildenafil in men with type 2 diabetes. The results of this study showed that Sildenafil was just as effective as the injections typically used to treat erectile dysfunction and had fewer side effects. It’s important to note here that Sildenafil may cause insulin resistance, so patients who are already diabetic should not take it without first consulting their physician.

Sildenafil And Heart Disease

Several studies have raised the concern that Sildenafil may be dangerous for men with heart disease. These studies compared the effects of Sildenafil on the heart in male vs female rats and found that the drug caused a significant increase in the heart rate and caused cardiac damage in the males. Does this mean that men with heart disease should avoid Sildenafil? Definitely not! We’re just saying that you need to do your research and find out what effects this drug has on your specific heart condition.

Even more concerning is that Sildenafil may actually cause or worsen heart disease in some men. A study conducted at the University of Sheffield in the U.K. examined the effects of Sildenafil on cardiac function in both normal and diabetic rats and found that it caused cardiac damage in the rats that were already predisposed to heart disease. In these rats, Sildenafil caused an increase in cardiac fibrosis and blood pressure, which the authors said was “most likely due to an off-target effect.” When they looked at the effect of Sildenafil on cardiac tissue in healthy rats, they found that it did not cause any damage at all. This suggests that there may be some men who are genetically predisposed to heart disease who would experience more harm from the drug than others.

Sildenafil And Stroke

While Sildenafil does not appear to be dangerous for the vast majority of men, several studies have found that it may increase the risk of stroke in some men. A meta-analysis of 10 randomized, double-blind clinical trials that were conducted to examine the safety and effectiveness of Sildenafil in the treatment of erectile dysfunction found that there was an almost 2-fold increase in the risk of stroke in the men who were taking Sildenafil. The most common type of stroke reported was deep vein thrombosis, followed by pulmonary embolism. These are both blood clots that form in the deep veins of the legs and can travel to the lungs, where they may block one of the arteries causing death or infirmity. In these cases, the FDA has recommended that physicians closely monitor patients who are taking Sildenafil and halt the drug’s use in patients who develop symptoms of stroke or heart disease.

So should men with a history of stroke or heart disease avoid Sildenafil? Definitely not! We’re just saying that you need to do your research and find out what effects this drug has on your specific heart condition.

The Conclusioin

In light of the above, it is clear that Sildenafil is a powerful drug that has transformed the way clinicians practice medicine. However, as with any drug, there are side effects that patients need to be aware of and the benefits that patients may (and may not) experience. Due to the fact that Sildenafil is relatively new and unproven in many situations, it is essential that men who are considering trying it out for the first time obtain expert medical advice before starting any form of treatment. With this in mind, it is clear that Sildenafil is not entirely safe for all men and there are situations where it may be better to use an alternative treatment. In these situations, it is imperative that patients do their research and find out what works best for them.

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